Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.

@article{Clark2006DeletionOG,
  title={Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.},
  author={Richard Hugh Clark and Julia Claire Kenyon and Nathan W. Bartlett and David C Tscharke and Geoffrey L Smith},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 1},
  pages={
          29-38
        }
}
Vaccinia virus (VACV) is the vaccine that was used to eradicate smallpox and is being developed as a recombinant vaccine for other pathogens. Removal of genes encoding immunomodulatory proteins expressed by VACV may enhance virus immunogenicity and improve its potential as a vaccine. Protein A41 is a candidate for removal, having sequence similarity to the VACV chemokine-binding protein, vCKBP, and an association with reduced inflammation during dermal infection. Here, it is shown that, at low… CONTINUE READING

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