Deletion of flbA results in increased secretome complexity and reduced secretion heterogeneity in colonies of Aspergillus niger.

@article{Krijgsheld2013DeletionOF,
  title={Deletion of flbA results in increased secretome complexity and reduced secretion heterogeneity in colonies of Aspergillus niger.},
  author={Pauline Krijgsheld and Benjamin M Nitsche and H. N. Post and Ana M. Levin and Wally H. M{\"u}ller and Albert J. R. Heck and Arthur F. J. Ram and A F Maarten Altelaar and Han A. B. W{\"o}sten},
  journal={Journal of proteome research},
  year={2013},
  volume={12 4},
  pages={1808-19}
}
Aspergillus niger is a cell factory for the production of enzymes. This fungus secretes proteins in the central part and at the periphery of the colony. The sporulating zone of the colony overlapped with the nonsecreting subperipheral zone, indicating that sporulation inhibits protein secretion. Indeed, strain ΔflbA that is affected early in the sporulation program secreted proteins throughout the colony. In contrast, the ΔbrlA strain that initiates but not completes sporulation did not show… CONTINUE READING