Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice

@article{Williams2016DeletionOF,
  title={Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice},
  author={Aislinn Joanmarie Williams and Patricia L. Yee and Mitchell Cincinnati Smith and Geoffrey G. Murphy and Hisashi Umemori},
  journal={Behavioural Brain Research},
  year={2016},
  volume={307},
  pages={11-17}
}
Specific growth factors induce formation and differentiation of excitatory and inhibitory synapses, and are essential for brain development and function. Fibroblast growth factor 22 (FGF22) is important for specifying excitatory synapses during development, including in the hippocampus. Mice with a genetic deletion of FGF22 (FGF22KO) during development subsequently have fewer hippocampal excitatory synapses in adulthood. As a result, FGF22KO mice are resistant to epileptic seizure induction. In… CONTINUE READING
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