Deletion of complement C4 and steroid 21-hydroxylase genes in the HLA class III region.

@article{Carroll1985DeletionOC,
  title={Deletion of complement C4 and steroid 21-hydroxylase genes in the HLA class III region.},
  author={Michael C Carroll and Astridur Palsdottir and K. Tertia Belt and Rodney R. Porter},
  journal={The EMBO journal},
  year={1985},
  volume={4 10},
  pages={2547-52}
}
Molecular maps have been prepared of the HLA region on human chromosome 6 that includes the complement C4 and steroid 21-hydroxylase genes (21-OH), using DNA of individuals deficient (QO) in either of the two forms C4A or C4B. In all, 18 haplotypes with C4A QO were examined by Southern analysis and two had deletions of 28-30 kb that included both the C4A and 21-OHA genes. Of six C4B QO haplotypes, one had a deletion that included both the C4B and 21-OHA genes. Thus, some of the C4 null alleles… CONTINUE READING