Deletion of an mmpL gene and multiple associated genes from the genome of the S strain of Mycobacterium avium subsp. paratuberculosis identified by representational difference analysis and in silico analysis.

@article{Marsh2005DeletionOA,
  title={Deletion of an mmpL gene and multiple associated genes from the genome of the S strain of Mycobacterium avium subsp. paratuberculosis identified by representational difference analysis and in silico analysis.},
  author={Ian B. Marsh and Richard J Whittington},
  journal={Molecular and cellular probes},
  year={2005},
  volume={19 6},
  pages={371-84}
}
Mycobacterium avium subsp. paratuberculosis (M. a. paratuberculosis) can be divided into two major strains, sheep (S) and cattle (C), based on cultural requirements, host specificity, degree of clumping of cells in suspension and minor genomic differences including copy number of insertion elements and point mutations. Representational difference analysis (RDA) with S strain as driver and C strain as tester was used to identify unique genomic regions. Three sequences (RDA1, RDA3 and RDA4) were… CONTINUE READING
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