Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.

@article{Liu2007DeletionOA,
  title={Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.},
  author={Wennuan Liu and Bao-li Chang and Scott S. Cramer and Patrick P. Koty and Tao Li and Jishan Sun and Aubrey R. Turner and Chris von Kap-Herr and Peggy Bobby and Jianyu Rao and S{\'i}qun Lilly Zheng and William B Isaacs and Jianfeng Xu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 17},
  pages={
          5028-33
        }
}
PURPOSE Chromosome 6q14-21 is commonly deleted in prostate cancers, occurring in approximately 22% of all tumors and approximately 40% of metastatic tumors. However, candidate prostate tumor suppressor genes in this region have not been identified, in part due to the large and broad nature of the deleted region implicated in previous studies. EXPERIMENTAL DESIGN We first used high-resolution Affymetrix single nucleotide polymorphism arrays to examine DNA from malignant and matched… CONTINUE READING

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