Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

@inproceedings{Ahlemeyer2012DeletionOA,
  title={Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain},
  author={Barbara Ahlemeyer and Magdalena Gottwald and Eveline Baumgart-Vogt},
  booktitle={Disease models & mechanisms},
  year={2012}
}
Impaired neuronal migration and cell death are commonly observed in patients with peroxisomal biogenesis disorders (PBDs), and in mouse models of this diseases. In Pex11β-deficient mice, we observed that the deletion of a single allele of the Pex11β gene (Pex11β(+/-) heterozygous mice) caused cell death in primary neuronal cultures prepared from the… CONTINUE READING