Deletion of a novel protein kinase with PX and FYVE-related domains increases the rate of differentiation of Trypanosoma brucei.

@article{Vassella2001DeletionOA,
  title={Deletion of a novel protein kinase with PX and FYVE-related domains increases the rate of differentiation of Trypanosoma brucei.},
  author={Erik Vassella and Richard A. Kraemer and Charles M. R. Turner and Miriam Wankell and Carl D Modes and Miriam van den Bogaard and Michael Boshart},
  journal={Molecular microbiology},
  year={2001},
  volume={41 1},
  pages={
          33-46
        }
}
Growth control of African trypanosomes in the mammalian host is coupled to differentiation of a non-dividing life cycle stage, the stumpy bloodstream form. We show that a protein kinase with novel domain architecture is important for growth regulation. Zinc finger kinase (ZFK) has a kinase domain related to RAC and S6 kinases flanked by a FYVE-related zinc finger and a phox (PX) homology domain. To investigate the function of the kinase during cyclical development, a stable transformation… CONTINUE READING
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