Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum.

@article{Zkny1997DeletionOA,
  title={Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum.},
  author={J{\'o}zsef Z{\'a}k{\'a}ny and Matthieu G{\'e}rard and Beno{\^i}t Favier and Denis Duboule},
  journal={The EMBO journal},
  year={1997},
  volume={16 14},
  pages={4393-402}
}
A phylogenetically conserved transcriptional enhancer necessary for the activation of Hoxd-11 was deleted from the HoxD complex of mice by targeted mutagenesis. While genetic and expression analyses demonstrated the role of this regulatory element in the activation of Hoxd-11 during early somitogenesis, the function of this gene in developing limbs and the urogenital system was not affected, suggesting that Hox transcriptional controls are different in different axial structures. In the trunk… CONTINUE READING