Deletion of Ultraconserved Elements Yields Viable Mice

@article{Ahituv2007DeletionOU,
  title={Deletion of Ultraconserved Elements Yields Viable Mice},
  author={Nadav Ahituv and Yiwen Zhu and Axel Visel and Amy E Holt and Veena Afzal and Len A. Pennacchio and Edward M. Rubin},
  journal={PLoS Biology},
  year={2007},
  volume={5},
  pages={456 - 465}
}
Ultraconserved elements have been suggested to retain extended perfect sequence identity between the human, mouse, and rat genomes due to essential functional properties. To investigate the necessities of these elements in vivo, we removed four noncoding ultraconserved elements (ranging in length from 222 to 731 base pairs) from the mouse genome. To maximize the likelihood of observing a phenotype, we chose to delete elements that function as enhancers in a mouse transgenic assay and that are… CONTINUE READING

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