Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer’s Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway

@article{Wang2017DeletionOT,
  title={Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer’s Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway},
  author={Lin Wang and Bing-jin Liu and Yun Cao and Wei-Qi Xu and Dong-Sheng Sun and Meng-zhu Li and Fang-Xiao Shi and Man Li and Q. I. Tian and Jian-Zhi Wang and Xinwen Zhou},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={4731-4744}
}
Although several studies have shown that type-2 cannabinoid receptor (CB2R) is involved in Alzheimer’s disease (AD) pathology, the effects of CB2R on AD-like tau abnormal phosphorylation and its underlying mechanism remain unclear. Herein, we employed the CB2R−/− mice as the animal model to explore roles of CB2R in regulating tau phosphorylation and brain function. We found that CB2R−/− mice display AD-like tau hyperphosphorylation, hippocampus-dependent memory impairment, increase of GSK3… CONTINUE READING