Deletion of Shank 1 Has Minimal Effects on the Molecular Composition and Function of Glutamatergic Afferent Postsynapses in the Mouse Inner Ear

@inproceedings{Braude2017DeletionOS,
  title={Deletion of Shank 1 Has Minimal Effects on the Molecular Composition and Function of Glutamatergic Afferent Postsynapses in the Mouse Inner Ear},
  author={Jeremy P. Braude and Sarath Vijayakumar and Katherine M. Baumgarner and Rebecca Laurine and Timothy A. Jones and M. Sherri and Jones and Sonya J. Pyott},
  year={2017}
}
Shank proteins (1–3) are considered the master organizers of glutamatergic postsynaptic densities in the central nervous system, and the genetic deletion of either Shank1, 2, or 3 results in altered composition, form, and strength of glutamatergic postsynapses. To investigate the contribution of Shank proteins to glutamatergic afferent synapses of the inner ear and especially cochlea, we used immunofluorescence and quantitative real time PCR to determine the expression of Shank1, 2, and 3 in… CONTINUE READING

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