Deletion of PPAR in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

@inproceedings{Jones2005DeletionOP,
  title={Deletion of PPAR in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance},
  author={Julie R. Jones and Cordelia J. Barrick and Kyoung-ah Kim and Jill Lindner and Bertrand Blondeau and Yuka Fujimoto and Masakazu Shiota and Robert A Kesterson and Barbara B. Kahn and Mark A Magnuson},
  year={2005}
}
Peroxisome proliferator-activated receptor (PPAR ) plays a crucial role in adipocyte differentiation, glucose metabolism, and other physiological processes. To further explore the role of PPAR in adipose tissues, we used a Cre loxP strategy to generate adipose-specific PPAR knockout mice. These animals exhibited marked abnormalities in the formation and function of both brown and white adipose tissues. When fed a high-fat diet, adiposespecific PPAR knockout mice displayed diminished weight gain… CONTINUE READING
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