Deletion of Nrf2 Exacerbates Oxidative Stress After Traumatic Brain Injury in Mice

@article{Lu2015DeletionON,
  title={Deletion of Nrf2 Exacerbates Oxidative Stress After Traumatic Brain Injury in Mice},
  author={Xinyu Lu and Han-dong Wang and Jian-guo Xu and Ke Ding and Tao Li},
  journal={Cellular and Molecular Neurobiology},
  year={2015},
  volume={35},
  pages={713-721}
}
Traumatic brain injury (TBI) is a worldwide public health and medical problem. Oxidative stress is recognized as an important contributing factor in the pathogenesis of TBI. The present study was designed to explore the anti-oxidative effect of Nuclear factor erythroid 2-related factor 2 (Nrf2) on brain damage induced by traumatic injury in a mouse model. Moderate weight-drop impact head injury was induced in adult male mice. The mice were randomly divided into four groups: Nrf2+/+ sham… CONTINUE READING
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