Deletion of Mir155 prevents Fas-induced liver injury through up-regulation of Mcl-1.

@article{Chen2015DeletionOM,
  title={Deletion of Mir155 prevents Fas-induced liver injury through up-regulation of Mcl-1.},
  author={Weina Chen and Chang Han and Jinqian Zhang and Kyoungsub Song and Ying Wang and Tong Wu},
  journal={The American journal of pathology},
  year={2015},
  volume={185 4},
  pages={
          1033-44
        }
}
Fas-induced apoptosis is involved in diverse liver diseases. Herein, we investigated the effect of Mir155 deletion on Fas-induced liver injury. Wild-type (WT) mice and Mir155 knockout (KO) mice were i.p. administered with the anti-Fas antibody (Jo2) to determine animal survival and the extent of liver injury. After Jo2 injection, the Mir155 KO mice exhibited prolonged survival versus the WT mice (P < 0.01). The Mir155 KO mice showed lower alanine aminotransferase and aspartate aminotransferase… Expand
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