Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.

@article{Mehta2007DeletionOL,
  title={Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.},
  author={Jawahar Lal Mehta and Nobuhito Sanada and Chang ping Hu and Jiawei Chen and Abhijit Dandapat and Fumiaki Sugawara and Hiroo Satoh and Kazuhiko Inoue and Yosuke Kawase and Kou-ichi Jishage and Hiroshi Suzuki and Motohiro Takeya and Laura Schnackenberg and Richard Beger and Paul L. Hermonat and Maria Thomas and Tatsuya Sawamura},
  journal={Circulation research},
  year={2007},
  volume={100 11},
  pages={1634-42}
}
Atherosclerosis is associated with oxidative stress and inflammation, and upregulation of LOX-1, an endothelial receptor for oxidized LDL (oxLDL). Here, we describe generation of LOX-1 knockout (KO) mice in which binding of oxLDL to aortic endothelium was reduced and endothelium-dependent vasorelaxation preserved after treatment with oxLDL (P<0.01 versus wild-type mice). To address whether endothelial functional preservation might lead to reduction in atherogenesis, we crossed LOX-1 KO mice… CONTINUE READING