Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

@inproceedings{AbdulHay2011DeletionOI,
  title={Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance},
  author={Samer O. Abdul-Hay and Dongcheul Kang and Melinda McBride and Lilin Li and Ji Zhao and Malcolm A Leissring},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Insulin-degrading enzyme (IDE) is widely recognized as the principal protease responsible for the clearance and inactivation of insulin, but its role in glycemic control in vivo is poorly understood. We present here the first longitudinal characterization, to our knowledge, of glucose regulation in mice with pancellular deletion of the IDE gene (IDE-KO mice). METHODOLOGY IDE-KO mice and wild-type (WT) littermates were characterized at 2, 4, and 6 months of age in terms of body… CONTINUE READING
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