Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Enhanced Working Memory and Deficit in Fear Conditioning

@inproceedings{Yadav2013DeletionOG,
  title={Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Enhanced Working Memory and Deficit in Fear Conditioning},
  author={Roopali Yadav and Brandon G. Hillman and Subhash C Gupta and Pratyush S Suryavanshi and Jay M. Bhatt and Ratnamala Pavuluri and Dustin J. Stairs and Shashank Manohar Dravid},
  booktitle={PloS one},
  year={2013}
}
Glutamate delta-1 (GluD1) receptors are expressed throughout the forebrain during development with high levels in the hippocampus during adulthood. We have recently shown that deletion of GluD1 receptor results in aberrant emotional and social behaviors such as hyperaggression and depression-like behaviors and social interaction deficits. Additionally, abnormal expression of synaptic proteins was observed in amygdala and prefrontal cortex of GluD1 knockout mice (GluD1 KO). However the role of… CONTINUE READING

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