Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Aberrant Emotional and Social Behaviors

@inproceedings{Yadav2012DeletionOG,
  title={Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Aberrant Emotional and Social Behaviors},
  author={Roopali Yadav and Subhash C Gupta and Brandon G. Hillman and Jay M. Bhatt and Dustin J. Stairs and Shashank Manohar Dravid},
  booktitle={PloS one},
  year={2012}
}
The delta family of ionotropic glutamate receptors consists of glutamate δ1 (GluD1) and glutamate δ2 (GluD2) receptors. While the role of GluD2 in the regulation of cerebellar physiology is well understood, the function of GluD1 in the central nervous system remains elusive. We demonstrate for the first time that deletion of GluD1 leads to abnormal emotional and social behaviors. We found that GluD1 knockout mice (GluD1 KO) were hyperactive, manifested lower anxiety-like behavior, depression… CONTINUE READING
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