Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)

@article{Vortkamp1992DeletionOG,
  title={Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)},
  author={Andrea Vortkamp and Thomas Franz and Manfred Gessler and K. H. Grzeschik},
  journal={Mammalian Genome},
  year={1992},
  volume={3},
  pages={461-463}
}
The dominant mouse mutant extra toes (Xt) is characterized by preaxial and postaxial polydactyly of the feet and a white belly spot. An interfrontal bone is present in the skull in 90% of heterozygotes compared with 50% of normal mice. Homozygous XtlXt embryos exhibit multiple skeletal defects, extreme polydactyly in both foreand hindlimbs, and malformations of the brain and the eye (Johnson 1967; Franz and Besecke 1991). Depending on the genetic background, Xt homozygotes die prenatally or… CONTINUE READING
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The development of the eye in homozygous mutants of the extra - toes locus of the mouse

  • T. Franz, A. Beseke
  • Anat Embryol
  • 1991

Evidence for alMism of the recessive insertional mutation add and the dominant mouse mutation extratoes ( Xt )

  • T. M. Pohl, M. G. Mattei, U. Rfither
  • Development
  • 1990

The GLI - Kriippel family of human genes

  • J. M. Ruppert, K. W. Kinzler, +5 authors S. J. O'Brien
  • Mol Cell Bioi
  • 1988

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