Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.

  title={Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.},
  author={Sunder Sims-Lucas and Luise Cullen-McEwen and Veraragavan P. Eswarakumar and David S. Hains and Kayle Kish and Brian Becknell and Jue Zhang and John F. Bertram and Fen Wang and Carlton M. Bates},
  journal={American journal of physiology. Renal physiology},
  volume={297 5},
Fibroblast growth factor receptor 2 (Fgfr2) signaling is critical in maintaining ureteric branching architecture and mesenchymal stromal morphogenesis in the kidney. Fibroblast growth factor receptor substrate 2alpha (Frs2alpha) is a major docking protein for Fgfr2 with downstream targets including Ets variant (Etv) 4 and Etv5 in other systems. Furthermore, global deletion of Frs2alpha causes early embryonic lethality. The purpose of the study was to determine the role of Frs2alpha in mediating… CONTINUE READING


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