Deletion of Epstein-Barr virus BFLF2 leads to impaired viral DNA packaging and primary egress as well as to the production of defective viral particles.

@article{Granato2008DeletionOE,
  title={Deletion of Epstein-Barr virus BFLF2 leads to impaired viral DNA packaging and primary egress as well as to the production of defective viral particles.},
  author={Marisa Granato and Regina Feederle and Antonella Farina and Roberta Gonnella and Roberta Piergiovanni Martin Carree Enrico Santarelli and Birgit Hub and Alberto Faggioni and H J Delecluse},
  journal={Journal of virology},
  year={2008},
  volume={82 8},
  pages={4042-51}
}
Previous genetic and biochemical studies performed with several members of the Alphaherpesvirus subfamily have shown that the UL31 and UL34 proteins are essential components of the molecular machinery that mediates the primary egress of newly assembled capsids across the nuclear membrane. Further, there is substantial evidence that BFLF2 and BFRF1, the respective positional homologs of UL31 and UL34 in the Epstein-Barr virus (EBV) genome, are also their functional homologs, i.e., that the UL31… CONTINUE READING