Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing

@inproceedings{Ackerman2017DeletionOE,
  title={Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing},
  author={Jessica E. Ackerman and Katherine T. Best and Regis J O'Keefe and Alayna E Loiselle},
  booktitle={Scientific Reports},
  year={2017}
}
Tendon injuries heal via scar tissue rather than regeneration. This healing response forms adhesions between the flexor tendons in the hand and surrounding tissues, resulting in impaired range of motion and hand function. Mechanistically, inflammation has been strongly linked to adhesion formation, and Prostaglandin E2 (PGE2) is associated with both adhesion formation and tendinopathy. In the present study we tested the hypothesis that deletion of the PGE2 receptor EP4 in S100a4-lineage cells… CONTINUE READING
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