Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

@article{Kishimoto2000DeletionOC,
  title={Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2},
  author={Toshimitsu Kishimoto and Jelena Radulovic and Marko Radulovic and C. Richard Lin and Christina Schrick and Farideh Hooshmand and Ola Hermanson and Michael G. Rosenfeld and Joachim Spiess},
  journal={Nature Genetics},
  year={2000},
  volume={24},
  pages={415-419}
}
Corticotropin-releasing hormone (Crh), a 41-residue polypeptide, activates two G-protein–coupled receptors, Crhr1 (refs 3–5) and Crhr2 (refs 6–9), causing (among other transductional events) phosphorylation of the transcription factor Creb (ref. 10). The physiologic role of these receptors is only partially understood. Here we report that male, but not female, Crhr2-deficient mice exhibit enhanced anxious behaviour in several tests of anxiety in contrast to mice lacking Crhr1 (refs 11,12). The… CONTINUE READING
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