Deletion of Chromosome 1, But Not Mutation of MEN-1, Predicts Prognosis in Sporadic Pancreatic Endocrine Tumors

Abstract

Pancreatic endocrine tumors (PETs) may be sporadic or inherited in the multiple endocrine neoplasia type 1 (MEN-1) syndrome. The inherited form is caused by mutations of the MEN-1 gene, which functions as a tumor suppressor gene and maps to chromosome 11q13. These tumors tend to have a better prognosis than their sporadic counterparts, which often have… (More)
DOI: 10.1007/s00268-002-4062-4

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