Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration.

  title={Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration.},
  author={Kylee L. Spencer and Michael A. Hauser and Lana M. Olson and Silke Schmidt and William K. Scott and Paul J. Gallins and Anita Agarwal and Eric A. Postel and Margaret A. Pericak-Vance and Jonathan L. Haines},
  journal={Human molecular genetics},
  volume={17 7},
Age-related macular degeneration (AMD) impairs vision for approximately 7.5 million Americans. Both susceptibility variants and protective haplotypes in the complement factor H (CFH) gene modulate risk for AMD. Recently, deletion of the 'CFH-related' genes CFHR1 and CFHR3 was found to be segregating with a particular CFH haplotype, which reduced the risk of AMD. We tested the deletion for association in a Caucasian population of 780 cases and 265 controls and examined its effect in the context… CONTINUE READING


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