Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation.

@article{Mactaggart2007DeletionOC,
  title={Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation.},
  author={Jason N Mactaggart and Wanfen Xiong and Rebecca A Knispel and Bernard Timothy Baxter},
  journal={Surgery},
  year={2007},
  volume={142 2},
  pages={284-8}
}
BACKGROUND Microscopic analysis of abdominal aortic aneurysms (AAAs) demonstrates an abundance of infiltrating leukocytes. The chemokine receptors CCR2, CCR5, and CXCR3 are associated with pathways implicated previously in aneurysm pathogenesis. We hypothesized that genetic deletions of CCR2, CCR5, and CXCR3 would limit leukocyte infiltration and aneurysm formation in a mouse model of AAA. METHODS CCR2(-/-), CCR5(-/-), CXCR3(-/-), and control mice of the same genetic background were subject… CONTINUE READING

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