Deletion of 1p loci and microsatellite instability in colorectal polyps.

  title={Deletion of 1p loci and microsatellite instability in colorectal polyps.},
  author={Ragnhild A. Lothe and Solveig Norheim Andersen and Bj\orn Hofstad and Gunn Iren Meling and P{\"a}ivi Peltom{\"a}ki and Sverre Heim and Anton Br\ogger and Morten Harald Vatn and Torleiv Ole Rognum and A. L. B\orresen},
  journal={Genes, chromosomes & cancer},
  volume={14 3},
Previous cytogenetic studies have indicated that a subset of large bowel adenomas have distal 1p deletions. We addressed this question by examining 70 sporadic polyps (63 adenomas, 5 hyperplastic polyps, and 2 polyps of undetermined histology) from 55 patients for alterations at eight loci on the short arm of chromosome 1 and found allelic imbalance (AI) or loss of one allele (LOH) in 14 (20%). The locus most frequently changed was MSI, which maps to 1p33-35. Fluorescence in situ hybridisation… CONTINUE READING


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