Deletion of β-catenin impairs T cell development

  title={Deletion of β-catenin impairs T cell development},
  author={Y. Xu and D. Banerjee and J. Huelsken and W. Birchmeier and J. Sen},
  journal={Nature Immunology},
  • Y. Xu, D. Banerjee, +2 authors J. Sen
  • Published 2003
  • Biology
  • Nature Immunology
  • T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the αβ TCR. Here we show that T cell–specific deletion of β-catenin impaired T cell development at the β-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, β-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T… CONTINUE READING

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    Publications referenced by this paper.
    Lymphostromal interactions in thymic development and function
    • 443
    • Open Access
    An HMG-box-containing T-cell factor required for thymocyte differentiation
    • 511
    • Open Access
    On the brink of becoming a T cell.
    • 97
    Signal transduction in thymus development.
    • 24