Deletion of β-catenin impairs T cell development

  title={Deletion of β-catenin impairs T cell development},
  author={Youyuan Xu and Daliya Banerjee and Joerg Huelsken and Walter Birchmeier and Jyoti Misra Sen},
  journal={Nature Immunology},
T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the αβ TCR. Here we show that T cell–specific deletion of β-catenin impaired T cell development at the β-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, β-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T… CONTINUE READING
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