Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13.

@article{Chakrabarti1998DeletionMO,
  title={Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13.},
  author={Rita Chakrabarti and Eri S. Srivatsan and Tony Wood and Patricia J. Eubanks and S A Sayed Ebrahimi and RichardA. Gatti and Edward P. Passaro and Mark P. Sawicki},
  journal={Genes, chromosomes & cancer},
  year={1998},
  volume={22 2},
  pages={
          130-7
        }
}
Multiple endocrine neoplasia type 1 syndrome (MEN1, MIM 131100), an autosomal dominant disease, is characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. These tumors also occur sporadically. Both the familial (MEN1) and the sporadic tumors reveal loss of heterozygosity (LOH) for chromosome band 11q13 sequences. Based on prior linkage and LOH analyses, the MEN1 gene was localized between PYGM and D11S460. Recently, the MEN1 gene (menin) has been cloned… CONTINUE READING
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