Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers.

@article{etin2008DeletionMO,
  title={Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers.},
  author={Esra Çetin and Beyhan Cengiz and Esra Gunduz and Mehmet Gunduz and Hitoshi Nagatsuka and L Bekir-Beder and Kunihiro Fukushima and Davut Pehlivan and N MOzaslan and Kazunori Nishizaki and Kenji Shimizu and Noriyuki Nagai},
  journal={Neoplasma},
  year={2008},
  volume={55 4},
  pages={299-304}
}
Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggressive in their biologic behavior. Inactivation of tumor suppressor gene (TSG) is one of the most critical steps leading to HNSCC. Loss of heterozygosity analysis is very sensitive method for the detection of frequent allelic loss in a chromosomal locus. This method has been considered as an important evidence for the localization of TSGs. We analyzed loss of heterozygosity (LOH) at chromosome… CONTINUE READING
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