Deletion mapping of 18q in conventional renal cell carcinoma.

@article{Hirata2005DeletionMO,
  title={Deletion mapping of 18q in conventional renal cell carcinoma.},
  author={Hiroshi Hirata and Hideyasu Matsuyama and Hiroaki Matsumoto and Yoshihito Korenaga and Chietaka Ohmi and Shigeru Sakano and Satoru Yoshihiro and Katsusuke Naito},
  journal={Cancer genetics and cytogenetics},
  year={2005},
  volume={163 2},
  pages={
          101-5
        }
}
Loss of heterozygosity (LOH) is frequently associated with the inactivation of tumor suppressor genes. 18q LOH has been frequently reported in colorectal cancer and lung cancer; however, allelic loss on 18q has not been investigated in renal cell carcinoma (RCC). We evaluated LOH on 18q using nine microsatellite markers in 126 with conventional RCC (cRCC). LOH was observed in more than one 18q microsatellite locus in 24 cRCC (19%). We found the highest frequency of LOH (13.5%) at 18q21.3, where… CONTINUE READING

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