Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.

@article{Cheng1995DeletionMI,
  title={Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.},
  author={Ngan Ching Cheng and Nadine Van Roy and Alvin J Chan and M M Beitsma and Andries Westerveld and Frank Speleman and Rogier Versteeg},
  journal={Oncogene},
  year={1995},
  volume={10 2},
  pages={291-7}
}
Neuroblastoma is characterized by deletions of the short arm of chromosome 1 (1p) and amplification of the N-myc oncogene. We have made somatic cell hybrids of two human neuroblastoma cell lines, one with and one without N-myc expression and amplification. The expression of the amplified N-myc gene is completely switched off in the hybrids. This suggests that N-myc expression results from loss of a repressor function. As N-myc amplification is associated with loss of heterozygosity (LOH) of… CONTINUE READING

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