Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen

@inproceedings{Taylor2012DeletionAA,
  title={Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen},
  author={Justin J Taylor and Ryan J. Martinez and Philip J. Titcombe and Laura O. Barsness and Stephanie R. Thomas and Na Zhang and Shoshana D. Katzman and Marc K Jenkins and Daniel M{\"u}ller},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
B cell tolerance to self-antigen is critical to preventing antibody-mediated autoimmunity. Previous work using B cell antigen receptor transgenic animals suggested that self-antigen-specific B cells are either deleted from the repertoire, enter a state of diminished function termed anergy, or are ignorant to the presence of self-antigen. These mechanisms have not been assessed in a normal polyclonal repertoire because of an inability to detect rare antigen-specific B cells. Using a novel… CONTINUE READING