Deletion analysis of the adenomatous polyposis coli and PTCH gene loci in patients with sporadic and nevoid basal cell carcinoma syndrome-associated medulloblastoma.

@article{Vortmeyer1999DeletionAO,
  title={Deletion analysis of the adenomatous polyposis coli and PTCH gene loci in patients with sporadic and nevoid basal cell carcinoma syndrome-associated medulloblastoma.},
  author={Alexander O. Vortmeyer and Theodora Stavrou and Debbie Selby and Guojun Li and Robert J. Weil and Weon Seo Park and Yong Wha Moon and R. C. Chandra and Alisa M Goldstein and Zhengping Zhuang},
  journal={Cancer},
  year={1999},
  volume={85 12},
  pages={2662-7}
}
BACKGROUND Medulloblastomas can occur sporadically or may be associated with hereditary tumor syndromes including familial adenomatous polyposis (FAP) and nevoid basal cell carcinoma syndrome (NBCCS). METHODS The authors performed a retrospective analysis for allelic deletion of the adenomatous polyposis coli (APC) and PTCH gene loci using paraffin embedded medulloblastoma specimens from patients who were admitted to Children's National Medical Center in Washington, DC, between 1982 and 1997… CONTINUE READING