Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization

@article{Knoblich1999DeletionAO,
  title={Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization},
  author={Juergen A. Knoblich and Lily Yeh Jan and Yuh-Nung Jan},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={155-158}
}
The Drosophila Inscuteable protein acts as a key regulator of asymmetric cell division during the development of the nervous system [1] [2]. In neuroblasts, Inscuteable localizes into an apical cortical crescent during late interphase and most of mitosis. During mitosis, Inscuteable is required for the correct apical-basal orientation of the mitotic spindle and for the asymmetric segregation of the proteins Numb [3] [4] [5], Prospero [5] [6] [7] and Miranda [8] [9] into the basal daughter cell… CONTINUE READING

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