Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain

  title={Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain},
  author={Ajay K. Yadav and Anagh Anant Sahasrabuddhe and Manjari Dimri and Prashant V. Bommi and Rachana Narendra Singh Sainger and Goberdhan P Dimri},
  booktitle={Molecular Cancer},
The polycomb group (PcG) protein BMI1 is an important regulator of development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell phenotype and oncogenesis. In particular, its overexpression has been found in several human malignancies including breast cancer. Despite its established role in stem cell maintenance, cancer and development, at present not much is known about the functional domains of BMI1 oncoprotein. In the present study, we carried out a deletion… CONTINUE READING
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