Deletion analysis of Ad5 E1a transcriptional control region: impact on tumor-selective expression of E1a and E1b

@article{Hedjran2011DeletionAO,
  title={Deletion analysis of Ad5 E1a transcriptional control region: impact on tumor-selective expression of E1a and E1b},
  author={Farah Hedjran and Kumar Shantanu and Reichhardt Tony},
  journal={Cancer Gene Therapy},
  year={2011},
  volume={18},
  pages={717-723}
}
The regulatory sequences upstream of E1a, the first viral protein expressed upon infection of cells with adenovirus, have binding sites for multiple transcription factors including two binding sites for E2f and five binding sites for Pea3. We evaluated the impact of deletions, which remove one or more of these transcription factor-binding sites on the expression of E1a in a panel of tumor cells and non-transformed cells. We demonstrated that specific deletions in the E1a enhancer markedly… CONTINUE READING

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