Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.

@article{Coschigano2003DeletionBN,
  title={Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.},
  author={Karen T. Coschigano and Amy N Holland and Markus E Riders and Edward O. List and Allan Flyvbjerg and John J. Kopchick},
  journal={Endocrinology},
  year={2003},
  volume={144 9},
  pages={3799-810}
}
GH participates in growth, metabolism, and cellular differentiation. To study these roles, we previously generated two different dwarf mouse lines, one expressing a GH antagonist (GHA) and the other having a disrupted GH receptor and binding protein gene (GHR -/-). In this study we compared the two dwarf lines in the same genetic background (C57BL/6J). One of the most striking differences between the mouse lines was their weight gain profile after weaning. The weights of the GHA dwarfs… CONTINUE READING
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