Deleting valine-125 and cysteine-126 in glycoprotein gI of pseudorabies virus strain NIA-3 decreases plaque size and reduces virulence in mice

Abstract

We investigated the function of antigenic domains on gI in virulence and immunogenicity. Three PRV gI mutants were constructed by deleting nucleotides coding for the following amino acids: valine-125 and cysteine-126, located in a discontinuous antigenic domain (M 303); glycine-59 and aspartic acid-60 located in a continuous antigenic domain (M 304); and… (More)
DOI: 10.1007/BF01378630

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@article{Jacobs1993DeletingVA, title={Deleting valine-125 and cysteine-126 in glycoprotein gI of pseudorabies virus strain NIA-3 decreases plaque size and reduces virulence in mice}, author={Liesbeth Jacobs and H. J. Rziha and Tjeerd G. Kimman and Arno L. J. Gielkens and Jan T. van Oirschot}, journal={Archives of Virology}, year={1993}, volume={131}, pages={251-264} }