Deleterious mutations, variable epistatic interactions, and the evolution of recombination.

@article{Otto1997DeleteriousMV,
  title={Deleterious mutations, variable epistatic interactions, and the evolution of recombination.},
  author={Sarah Perin Otto and Marcus W. Feldman},
  journal={Theoretical population biology},
  year={1997},
  volume={51 2},
  pages={
          134-47
        }
}
In this paper, we examine the conditions that allow increased recombination to evolve in the presence of recurrent deleterious mutation. We focus on a three-locus model first studied by Feldman et al. (1980), which follows the dynamics of a modifier locus that alters the recombination rate between two loci subject to deleterious mutation. Although Feldman et al. (1980) indicated that increased recombination might be favored if there is diminishing-returns epistasis, we show that alleles that… Expand
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It is shown that only one of these methods is likely to give useful results: crossing individuals that have very different numbers of deleterious mutations, and comparing the mean log fitness of the parents with that of their offspring. Expand
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  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2010
TLDR
Arguments against deterministic and stochastic explanations for high recombination rates in organisms are illustrated by comparing the interaction between good and bad mutations at unlinked loci under the infinitesimal model. Expand
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