Deleterious effects of lack of cardiac PAI-1 after coronary occlusion in mice and their pathophysiologic determinants


We sought to delineate mechanisms through which the lack of plasminogen activator inhibitor (PAI)-1 in the heart affects remodeling of the heart early after myocardial infarction (MI). MI was induced by coronary occlusion in 10-weeks old PAI-1 knockout (KO) and control mice. Three days after MI, systolic and diastolic function was assessed with high… (More)
DOI: 10.1007/s00418-007-0300-z


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