Deleterious effect of late menarche on distal tibia microstructure in healthy 20-year-old and premenopausal middle-aged women.

@article{Chevalley2009DeleteriousEO,
  title={Deleterious effect of late menarche on distal tibia microstructure in healthy 20-year-old and premenopausal middle-aged women.},
  author={T Chevalley and J Ph Bonjour and Serge Livio Ferrari and Ren{\'e} R Rizzoli},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2009},
  volume={24 1},
  pages={
          144-52
        }
}
Late menarche is a risk factor for fragility fractures. We hypothesized that pubertal timing-dependent alterations in bone structural components would persist from peak bone mass to menopause, independent of premenopausal bone loss. We studied the influence of menarcheal age (MENA) on femoral neck BMD (FN aBMD) by DXA and microstructure of distal tibia by HR-pQCT in healthy young adult (YAD; 20.4 +/- 0.6 [SD] yr, n = 124) and premenopausal middle-aged (PREMENO; 45.8 +/- 3.4 yr, n = 120) women… CONTINUE READING
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