Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

@inproceedings{Selman2013DeleteriousCO,
  title={Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal},
  author={Colin Selman and Jane S. McLaren and Andrew R Collins and Garry G. Duthie and John R Speakman},
  booktitle={Biology letters},
  year={2013}
}
While oxidative damage owing to reactive oxygen species (ROS) often increases with advancing age and is associated with many age-related diseases, its causative role in ageing is controversial. In particular, studies that have attempted to modulate ROS-induced damage, either upwards or downwards, using antioxidant or genetic approaches, generally do not show a predictable effect on lifespan. Here, we investigated whether dietary supplementation with either vitamin E (α-tocopherol) or vitamin C… CONTINUE READING
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Deleterious consequences of antioxidant supplementation on lifespan in a wildderived mammal

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