Deleterious Effects of Mild Hypothermia in Septic Rats Are Ameliorated by Granulocyte Colony-stimulating Factor

@article{Torossian2003DeleteriousEO,
  title={Deleterious Effects of Mild Hypothermia in Septic Rats Are Ameliorated by Granulocyte Colony-stimulating Factor},
  author={Alexander Torossian and Sebastian Ruehlmann and M. Middeke and Daniel I. Sessler and Wilfried Lorenz and Hinnerk F. Wulf and Artur Bauhofer},
  journal={Anesthesiology},
  year={2003},
  volume={99},
  pages={1087-1092}
}
Background The authors studied the effects of mild hypothermia on the outcome in a rat model of intraabdominal sepsis and tested whether granulocyte colony-stimulating factor (G-CSF) augments the host response and improves outcome during mild hypothermia. Methods A rat model of peritoneal contamination and infection with human stool bacteria was used to simulate clinical trials that included increasing complexity. In trial 1, postoperative hypothermia (32°C) was compared with normothermia (38°C… Expand
Mild preseptic hypothermia is detrimental in rats*
TLDR
In this rat model of intra-abdominal sepsis, mild preseptic hypothermia (32°C) reduced survival, impaired granulocyte recruitment, and changed cytokine balance, suggesting immunosuppression. Expand
Effect of hypothermia on splenic leukocyte modulation and survival duration in severely septic rats.
TLDR
Moderate hypothermic therapy significantly prolongs the survival duration of rats with severe septic shock and dampens the inflammatory response during septicshock by modulating the spleen to an anti-inflammatory mode and preventing theSpleen from releasing activated splenic leukocytes into the blood. Expand
Effect of therapeutic hypothermia according to severity of sepsis in a septic rat model.
TLDR
In this rat model of severe septic shock, therapeutic HT showed beneficial effects and did not show protective effect in the moderate sepsis model, while in the SSSM, there was no such beneficial effect. Expand
Correction of perioperative hypothermia decreases experimental sepsis mortality by modulating the inflammatory response
TLDR
Correction of perioperative hypothermia improves survival after sepsis by appropriately modulating the early inflammatory response, reflecting a blunting but not complete inhibition of the inflammatory response. Expand
Therapeutic hypothermia attenuates liver injury in polymicrobial sepsis model of rats via Akt survival pathway.
TLDR
Therapeutic hypothermia attenuated liver injury in a polymicrobial sepsis model of rats by enhancing the Akt signaling pathway and decreasing apoptosis. Expand
Granulocyte colony-stimulating factor prophylaxis improves survival and inflammation in a two-hit model of hemorrhage and sepsis*
TLDR
Hemorrhage (first hit) sensitized the host for a second hit of polymicrobial PCI independent of the timing and G-CSF prophylaxis improved survival and clearance of microbes and reduced the proinflammatory chemokine macrophage inflammatory protein-2 in the lung. Expand
Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation.
TLDR
It is demonstrated that naturally occurring hypothermia is more advantageous than fever in severe forms of aseptic (LPS- induced) or septic (E. coli-induced) systemic inflammation, which provides new grounds for the management of this deadly condition. Expand
Differential effects of antibiotics in combination with G-CSF on survival and polymorphonuclear granulocyte cell functions in septic rats
TLDR
Improved survival with the combination coamoxiclav plus G-CSF improved the survival rate and the selection of the antibiotic for combination with G- CSF in sepsis treatment should be guided not only by the bacteria to be eliminated, but also by the effects on antimicrobial functions of PMNs and the cytokine response. Expand
Dependence of Positive Effects of Granulocyte Colony-stimulating Factor on the Antibiotic Regimen: Evaluation in Rats with Polymicrobial Peritonitis
We tested the hypothesis that the ability of granulocyte colony-stimulating factor (G-CSF) to prevent death from fecal peritonitis is influenced by the composition of the antibiotic regimen withExpand
Direct influence of mild hypothermia on cytokine expression and release in cultures of human peripheral blood mononuclear cells.
TLDR
It is demonstrated that the direct influence of hypothermia on cytokine expression and release from PBMC is not uniform, and reduction of IL-2 production might play a crucial role in the impairment of immune response inHypothermia. Expand
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