Deleterious Effects of Chronic Folate Deficiency in the Ts65Dn Mouse Model of Down Syndrome

@inproceedings{Helm2017DeleteriousEO,
  title={Deleterious Effects of Chronic Folate Deficiency in the Ts65Dn Mouse Model of Down Syndrome},
  author={Susan Edgar Helm and Morgan B Blayney and Taylor Whited and Mahjabin Noroozi and Sen Lin and Semira Kern and David Vincent Green and Ahmad Salehi},
  booktitle={Front. Cell. Neurosci.},
  year={2017}
}
Folate is an important B vitamin naturally found in the human diet and plays a critical role in methylation of nucleic acids. Indeed, abnormalities in this major epigenetic mechanism play a pivotal role in the pathogenesis of cognitive deficit and intellectual disability in humans. The most common cause of cognitive dysfunction in children is Down syndrome (DS). Since folate deficiency is very common among the pediatric population, we questioned whether chronic folate deficiency (CFD… CONTINUE READING
1
Twitter Mention

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Risk factors for Down syndrome

  • Archives of Toxicology
  • 2016
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Nest building is impaired in the Ts 65 Dn mouse model of Down syndrome and rescued by blocking 5 HT 2 a receptors

H. C. Heller, A. Salehi, +3 authors S. Moghadam
  • Neurobiol . Learn . Mem .
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Down Syndrome

M. W. 0836-z McNerney, W. C. Mobley, A. Salehi
  • 2017
VIEW 1 EXCERPT