Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A.

@article{Crume2009DelayingTO,
  title={Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A.},
  author={Kevin Patrick Crume and David O'Sullivan and John Holmes Miller and Peter T Northcote and Anne Camille La Flamme},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={86 4},
  pages={
          949-58
        }
}
The hallmark of autoimmunity is the activation and proliferation of autoreactive lymphocytes. Therefore, one potential strategy to treat autoimmunity is to target the proliferating autoreactive lymphocytes with antimitotic drugs. Paclitaxel and peloruside are two microtubule-stabilizing drugs that halt cell proliferation by stabilizing microtubules in the G(2)/M phase of the cell cycle. C57BL/6 mice treated for 5 consecutive days with paclitaxel or peloruside had a reduced incidence and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Fc receptor-ligating complexes improve the course of experimental autoimmune encephalomyelitis by enhancing basal Th2 responses

A. C. La Flamme, M. Harvie, +3 authors B. T. Bäckström
  • Immunol. Cell Biol
  • 2006
VIEW 1 EXCERPT

Insights into the mechanism of microtubule stabilization by Taxol.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006

Similar Papers

Loading similar papers…