Delaying the mitochondrial decay of aging in the brain

  title={Delaying the mitochondrial decay of aging in the brain},
  author={Bruce N. Ames and Jiankang Liu and Hani Atamna and Tory M. Hagen},
  journal={Clinical Neuroscience Research},
Oxidative mitochondrial decay is a major contributor to aging and neural degeneration. In old rats (vs. young rats) mitochondrial membrane potential, cardiolipin level, respiratory control ratio, and cellular O2 uptake are lower; oxidants/O2, neuron RNA oxidation, and mutagenic aldehydes from lipid peroxidation are higher. Ambulatory activity and cognition declines with age. Feeding old rats for a few weeks with acetyl-L-carnitine (ALCAR), a mitochondrial metabolite, plus R-lipoic acid (LA), a… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations

Optimal micronutrients delay mitochondrial decay and age-associated diseases.

Mechanisms of ageing and development • 2010
View 4 Excerpts

Similar Papers

Loading similar papers…