Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.

@article{Goot2012DelayingAA,
  title={Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.},
  author={Annemieke T van der Goot and Wentao Zhu and Rafael P. V{\'a}zquez-Manrique and Ren{\'e}e I. Seinstra and Katja Dettmer and Helen Michels and Francesca Farina and Jasper Krijnen and Ronald Melki and Rogier C. Buijsman and Mariana Ruiz Silva and Karen L. Thijssen and Ido P. Kema and Christian N{\'e}ri and Peter J. Oefner and Ellen A. A. Nollen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 37},
  pages={14912-7}
}
Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-related neurological diseases like Parkinson and Alzheimer's diseases. Here, we identify tryptophan 2,3-dioxygenase (tdo-2), the first enzyme in the kynurenine pathway of tryptophan degradation, as a metabolic regulator of age-related α-synuclein toxicity in a Caenorhabditis elegans model. Depletion of tdo-2 also suppresses toxicity of other heterologous aggregation-prone proteins, including amyloid… CONTINUE READING
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