Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats.

@article{Mokudai2000DelayedTW,
  title={Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats.},
  author={Toshihiko Mokudai and Issam A. Ayoub and Yoshihiko Sakakibara and Eun Ja Lee and Christopher S Ogilvy and Kenneth I. Maynard},
  journal={Stroke},
  year={2000},
  volume={31 7},
  pages={1679-85}
}
BACKGROUND AND PURPOSE We have previously shown that nicotinamide (NAm) acutely reduces brain infarction induced by permanent middle cerebral artery occlusion (MCAo) in rats. In this study, we investigate whether NAm may protect against ischemia/reperfusion injury by improving sensory and motor behavior as well as brain infarction volumes in a model of transient focal cerebral ischemia. METHODS Forty-eight male Wistar rats were used, and transient focal cerebral ischemia was induced by MCAo… CONTINUE READING

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References

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Showing 1-10 of 34 references

D - Amphetamineinduced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment

Eliasson MJL, K Sampei, +7 authors SH Snyder
Brain Res Bull • 1999

GPI - 6150 , a potent PARP inhibitor , reduces infarct size following permanent and transient focal cerebral ischemia

J Zhang, VL Dawson, TM Dawson, SH Snyder
Soc Neurosci Abstr • 1999

Magnetic resonance imaging of perfusion in rat cerebral 9 L tumor after nicotinamide administration

GN Kryzhanovskii, AA Shandra, RF Makul’kin, BA Lokasiuk, LS Godlevskii
Int J Radiat Oncol Biol Phys • 1999

Recommen - dations for standards regarding preclinical neuroprotective and restorative drug development

J Koizumi, Y Yoshida, T Nakazawa, G Ooneda
1999

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